ENLIVEN Clinical Trial for PVNS, GCTTS & TGCT
Thank you for your interest in the ENLIVEN study.
About TGCT-PVNS or GCT-TS
PVNS or GCT-TS
Tenosynovial giant cell tumor (or TGCT) is a rare disease in which tumors grow in the tissue surrounding the joint area.* There are 2 broad types of TGCT, localized and diffuse. Localized TGCT, also known as giant cell tumor of the tendon sheath (GCT-TS), usually affects the hand, wrist, ankle, and/or foot. Diffuse TGCT generally impacts larger joints and is also known as pigmented villonodular synovitis (PVNS). 75% of diffuse TGCT cases involve the knee. The growing tumor and inflammation can cause pain and swelling, and greatly impact mobility. A common treatment is surgical removal of the lesion, but this may not relieve all of the symptoms associated with TGCT. Also, TGCT has about a 15%-45% chance of coming back, depending on form and location.
Tenosynovial giant cell tumor (TGCT) includes pigmented villonodular synovitis (PVNS) and giant cell tumor of the tendon sheath (GCT-TS).